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The STEP trials demonstrated that semaglutide produces sustained weight loss of 15-22% over 68 weeks in people with overweight or obesity, while the SURMOUNT trials showed tirzepatide delivering even greater reductions of 20-22% at standard doses

Those who used semaglutide were less likely to have a medical encounter that included a diagnosis of tobacco use disorder, prescribing of smoking cessation medication, or smoking cessation counseling during the study timeframe

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Diuretics Mechanism: Increase sodium and water excretion blood volume blood pressure Types & Examples: Thiazide: Hydrochlorothiazide, Chlorthalidone Loop: Furosemide, Bumetanide Potassium-sparing: Spironolactone, Amiloride Key Points: First-line for uncomplicated hypertension, especially thiazides 2